7-substituted fused ring tetracycline compounds

摘要

A 7-substituted fused ring tetracycline compound of formula (I):
wherein:
X
is CR 6 R 6' ;
R 4
and R 4' are each alkyl;
R 5
is hydrogen, hydroxyl, or a prodrug moiety;
R 6 and R 6'
are each independently hydrogen, hydroxyl, alkyl, or taken together, alkenyl;
Y and Y'
are each independently optionally substituted C, N, O, or S;
m
is 1 or 2; or a pharmaceutically acceptable salt thereof.