发明名称 |
Method for treatment of tumors using nucleic acid ligands to pdgf |
摘要 |
A method is provided for treating solid tumors comprising administering a composition a PDGF aptamer and a cytotoxic agent. In a preferred embodiment the PDGF aptamer is identified using the SELEX process for the Systemic Evolution of Ligands by Exponential enrichment. A method is also provided for reducing the interstitial fluid pressure (IFP) of a solid tumor comprising administering a PDGF aptamer. Finally, a method is provided for increasing the uptake of cytotoxic agents into a tumor comprising administering a composition comprising a PDGF aptamer and a cytotoxic agent. |
申请公布号 |
AU6325101(A) |
申请公布日期 |
2001.11.26 |
申请号 |
AU20010063251 |
申请日期 |
2001.05.17 |
申请人 |
GILEAD SCIENCES, INC. |
发明人 |
KRISTIAN PIETRAS;ARNE OSTMAN;KRISTOFER RUBIN;CARL-HENRIK HELDIN |
分类号 |
A61K38/00;C07B61/00;C07H21/00;C12N15/115;C12Q1/68;C40B50/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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