发明名称 |
Inhibition of interaction of psd93 and psd95 with nnos and nmda receptors |
摘要 |
PSD-95/SAP90 antisense-treated animals not only experience a significant decrease in MAC for isoflurane, but also experience an attenuation in the NMDA-induced increase in isoflurane MAC. PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. Suppression of the expression of PSD-95/SAP90 in the spinal cord significantly attenuates responses to painful stimuli mediated through the N-methyl-D-aspartate receptor activation. In spinal cord neurons PSD-95/SAP90 interacts with the N-methyl-D-aspartate receptor subunits 2A/2B. Activation of the N-methyl-D-aspartate receptor in spinal hyperalgesia results in association of the N-methyl-D-aspartate receptor with PSD-95/SAP90. PSD-95/SAP90 is required for hyperalgesia triggered via the N-methyl-D-aspartate receptor at the spinal cord level. |
申请公布号 |
AU6150101(A) |
申请公布日期 |
2001.11.26 |
申请号 |
AU20010061501 |
申请日期 |
2001.05.14 |
申请人 |
THE JOHNS-HOPKINS UNIVERSITY;ROGER A. JOHNS;YUANXIANG TAO |
发明人 |
ROGER A. JOHNS;YUANXIANG TAO |
分类号 |
A61K38/00;A61K38/17;A61K45/06;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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