发明名称 |
A process for the preparation of ampicillin |
摘要 |
<p>Ampicillin is produced in a batch process by enzymatic acylation of 6-aminopenicillanic acid (6-APA) with the aid of phenylglycine derivative such as D-phenylglycine amide. High conversions of phenylglycine derivative may be achieved by having the total concentration in the reaction mixture of 6-APA and ampicillin greater than 250 mM and the molar ration of total quantity of phenylglycine derivative to total quantity of 6-APA less than 2.5. Higher yields of ampicillin may be achieved when the amount of dissolved 6-APA is kept low, e.g. below 300 mM.</p> |
申请公布号 |
IN186863(B) |
申请公布日期 |
2001.11.24 |
申请号 |
IN1224MA1998 |
申请日期 |
1998.06.05 |
申请人 |
CHEMFERM V.O.F. |
发明人 |
MOODY HAROLD MONRO;BOESTEN WILHELMUS HUBERTUS JOSEPH |
分类号 |
C12P37/04;(IPC1-7):C12P37/00 |
主分类号 |
C12P37/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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