GENE THAT IMPARTS SELECTIVE PROLIFERATION ACTIVITY

摘要

Selective amplification of cells is enabled by introducing into cells a gene encoding a fusion protein comprising (a) a mutant estrogen receptor that is unresponsive to a estrogen and that is responsive to a tamoxifen, the derivative thereof, or the metabolite thereof, and (b)_a domain that imparts proliferation activity to the cells upon the association and stimulating the cells with the ligand.