发明名称 |
PYRIDAZIN-3-ONE DERIVATIVES AND MEDICINES CONTAINING THE SAME |
摘要 |
<p>Objects of the invention are to provide compounds having excellent activity against interleukin-1 beta production and also medicines comprising them as effective ingredients. Pyridazin-3-one derivatives represented by the following formula (1): <CHEM> wherein Ar<1> represents a substituted or unsubstituted aromatic group, Ar<2> represents a phenyl group having a substituent at least at the 4-position thereof, R<1> represents a linear or branched alkyl group, an alkyl group having a cyclic structure, a substituted or unsubstituted phenyl group or a substituted or unsubstituted phenyl(lower alkyl) group, and R<2> represents a cyano group, a carboxyl group, a (lower alkoxy)carbonyl group, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted carbamoyl group, or salts thereof; and medicines comprising them as effective ingredients.</p> |
申请公布号 |
EP1156039(A1) |
申请公布日期 |
2001.11.21 |
申请号 |
EP20000905344 |
申请日期 |
2000.02.25 |
申请人 |
KOWA CO., LTD. |
发明人 |
OHKUCHI, MASAO;KYOTANI, YOSHINORI;SHIGYO, HIROMICHI;YOSHIZAKI, HIDEO;KOSHI, TOMOYUKI;KITAMURA, TAKAHIRO;MATSUDA, TAKAYUKI;YASUOKA, KYOKO;FURUYAMA, TOMOKO |
分类号 |
A61P1/04;C07D237/14;A61K31/00;A61K31/50;A61K31/501;A61P1/00;A61P9/00;A61P9/10;A61P19/00;A61P19/02;A61P19/10;A61P29/00;A61P37/00;A61P37/06;C07D209/00;C07D213/00;C07D237/00;C07D237/24;C07D401/12;C07D403/06;(IPC1-7):C07D237/24 |
主分类号 |
A61P1/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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