发明名称 |
Inhibition of binding of complement Factor H |
摘要 |
Pathogen-specific peptide chains are provided which prevent pathogens from escaping complement-mediated lysis. The peptide chains bind to known binding sites on pathogens to which complement regulators such as complement Factor H bind. By occupying the binding sites and thereby preventing the binding of the complement regulators to the pathogen, the peptides prevent the pathogen from blocking or suppressing the function of the complement regulators in the complement-mediated lysis process.
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申请公布号 |
US6319890(B1) |
申请公布日期 |
2001.11.20 |
申请号 |
US19960775496 |
申请日期 |
1996.12.30 |
申请人 |
DIERICH MANFRED P.;CLIVIO ALBERTO;STOIBER HERIBERT |
发明人 |
DIERICH MANFRED P.;CLIVIO ALBERTO;STOIBER HERIBERT |
分类号 |
A61K38/00;C07K14/47;(IPC1-7):A61K38/08;A61K38/12;C07K7/06;C07K7/64 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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