GASTRIN AND CHOLECYSTOKININ RECEPTOR LIGANDS (II)

摘要

Compounds of formula (I) and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. X and Y are independently =N-, -N(R<5>)- (R<5> being selected from H, Me, Et, Pr, Bn, -OH and -CH2COOR<6>, wherein R<6> represents H, Me, Et, Pr or Bn), =CH-, -S-, or -O-; R<1> is H or C1-C15 hydrocarbyl wherein up to three C atoms may optionally be replaced by N, O and/or S atoms, and up to three H atoms may optionally be replaced by halogen atoms; R<2> is selected from H, Me, Et, Pr and OH, each R<2> being independently selected from H, Me, Et, Pr and OH when n is greater than 1; R<3> (when n is 1) is selected from H, Me, Et and Pr; or (when n is greater than 1) each R<3> is independently selected from H, Me, Et and Pr, or two R<3> groups on neighbouring carbon atoms are linked to form a C3 to C6 carbocyclic ring, or two R<3> groups are absent from neighbouring carbon atoms which are linked by a double bond; or R<2> and R<3> on the same carbon atom together represent an =O group; R<4> is H or C1-C15 hydrocarbyl wherein up to three C atoms may optionally be replaced by N, O and/or S atoms, and up to three H atoms may optionally be replaced by halogen atoms; Z is a diradical derived from an optionally substituted aromatic or non-aromatic C5 or C6 carbocycle, wherein 1, 2 or 3 C atoms are optionally replaced by N, O and/or S; Q is a 6-membered aromatic carbocycle (optionally substituted with 1 or 2 V groups and/or 1, 2 or 3 T groups) wherein 1, 2 or 3 C atoms are optionally replaced by N; V is -CO-NH-SO2-Ph, -SO2-NH-CO-Ph, -CH2OH, or a group of the formula -R<7>U, (wherein U is -COOH, tetrazolyl, -CONHOH or -SO3H; and R<7> is a bond; C1 to C6 hydrocarbylene, optionally substituted by hydroxy, amino or acetamido; -O-(C1 to C3 alkylene)-; -SO2NR<8>-CHR<9>-; -CO-NR<8>-CHR<9>-, R<8> and R<9> being independently selected from H and methyl; or -NH-(CO)c-CH2-, c being 0 or 1); T is C1 to C6 hydrocarbyl, -NR<10>R<11> (wherein R<10> and R<11> are independently selected from H, Me, Et, Pr or Bn), -OMe, -OH, -CH2OH, halogen or trihalomethyl. Compositions comprising a compound of formula (I) are also described.