MALONANILIC ACID DERIVATIVES, MEDICINAL COMPOSITIONS CONTAINING THE SAME AND USE THEREOF

摘要

Compounds represented by the general formula (I) or pharmacologically acceptable salts thereof which have excellent effects of lowering neutral fat level and non-HDL cholesterol level in the blood, inhibiting or suppressing the accumulation of neutral fat in the liver and protecting or ameliorating the liver function and, therefore, are useful as preventives or remedies for circulatory diseases such as hyperlipemia, arteriosclerosis, fatty liver and hepatitis. In said formula, wherein W represents oxygen, sulfur, methylene, etc.; R represents hydrogen, C1-6 alkyl or arylalkyl; R<1> and R<2> represent each alkyl, halogeno, etc.; R<3> represents hydrogen, alkyl, halogeno, etc.; Y represents alkyl, -Q-T (wherein Q represents oxygen, methylene, hydroxymethylene, etc.; and T represents optionally substituted aryl, etc.); and Z represents hydrogen, alkoxy, etc.