发明名称 |
METHODS OF FACILITATING VASCULAR GROWTH IN CARDIAC MUSCLE AND METHODS FOR THE PRODUCTION OF RECOMBINANT EMAP II |
摘要 |
A method of facilitating vascular growth in cardiac muscle of a subject in need of such treatment comprises inhibiting EMAP II activity in said subject by an amount effective to stimulate vascular growth in said cardiac muscle. The inhibiting step may be carried out by any suitable means, such as: By administering a compound (e.g., an antibody) that specifically binds to EMAP II to said subject in an amount effective to stimulate vascular growth in said cardiac muscle; by downregulating EMAP II expression in said subject by an amount effective to stimulate vascular growth in said cardiac muscle (e.g., by administration of an antisense olgionucleotide); or by administering an EMAP II receptor antagonist to said subject in an amount effective to stimulate vascular growth in said cardiac muscle.
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申请公布号 |
WO0147518(A8) |
申请公布日期 |
2001.11.15 |
申请号 |
WO2000US33467 |
申请日期 |
2000.12.08 |
申请人 |
CHILDRENS HOSPITAL LOS ANGELES RESEARCH INSTITUTE;SCHWARZ, MARGARET |
发明人 |
SCHWARZ, MARGARET |
分类号 |
A61K31/4178;A61K38/00;C07K14/52;C07K16/24;(IPC1-7):A61K31/417;A61K48/00 |
主分类号 |
A61K31/4178 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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