REPAIR OF NERVE DAMAGE

摘要

The invention provides use of an MGF (mechano-growth factor) Insulin-like Growth Factor I (IGF-I) isoform comprising amino acid sequences encoded by nucleic acid sequences of IGF-I exons 4,5 and 6 and in the reading frame of MGF and having the ability to reduce motoneurone loss by 20% or greater in response to nerve avulsion in the manufacture of a medicament for the treatment of nerve damage by localisation of MGF at the site of the damage.