SERINE PROTEASE INHIBITORS (SPN43A) FROM DROSOPHILA

摘要

Tree related Drosophila genes, coding for the serine protease inhibitors (serpins) Spn43a and Spn43Ac, have been characterised, and their nucleic acid and encoded amino acid sequences are provided herein. Developmental expression profiles and in situ hybridisation patterns for the encoded proteins have been obtained. Transgenic experiments on mutant forms of the genes have demonstrated a link between mutations in one of the genes and the occurrence of a characteristic mutant phenotype of Drosophila flies. Materials, methods and uses based on this discovery are also described.