| 发明名称 |
SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS |
| 摘要 |
Compounds of formula (I) wherein X is oxygen or sulfonyl, R is a ring, R<1> is cycloalkyl, y and z are 0 or 1, and R<2> is -CO-NHR<3> or a heteroaromatic ring having a ring nitrogen atom adjacent to the connecting ring carbon atom, are active as glucokinase activators to increase insulin secretion, which makes them useful for treating type II diabetes. |
| 申请公布号 |
WO0185706(A1) |
申请公布日期 |
2001.11.15 |
| 申请号 |
WO2001EP04777 |
申请日期 |
2001.04.27 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CORBETT, WENDY, LEA;HAYNES, NANCY-ELLEN;SARABU, RAMAKANTH |
| 分类号 |
C07D295/14;A61K31/17;A61K31/405;A61K31/426;A61K31/427;A61K31/44;A61K31/4402;A61K31/4406;A61K31/444;A61K31/5375;A61P3/10;A61P43/00;C07B53/00;C07C273/18;C07C275/50;C07C315/04;C07C317/44;C07D209/18;C07D213/56;C07D213/74;C07D213/75;C07D213/80;C07D213/803;C07D277/20;C07D277/44;C07D277/46;C07D277/56;C07D295/155;C07D417/12;(IPC1-7):C07D277/46;A61K31/442;A61K31/404 |
主分类号 |
C07D295/14 |
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