METHOD FOR THE PREPARATION OF POLYMERIC MICELLE VIA PHASE SEPARATION OF BLOCK COPOLYMER
摘要
A method for preparing a biodegradable polymeric micellar composition using liquid polyethylene glycol as a phase separation medium comprising mixing an effective amount of a hydrophobic drug, an amphiphilic block copolymer and a phase separation medium comprising liquid poly(ethylene glycol), stirring and heating to give a solution; cooling and stirring the solution until it forms a polymeric micelle by phase separation; diluting the polymeric micelle solution in distilled water and then dialyzing it against excess water to remove the liquid polyethylene glycol; and freeze-drying the dialyzed aqueous solution to give a polymeric micellar composition in a powdered state.
申请公布号
WO0185216(A1)
申请公布日期
2001.11.15
申请号
WO2001KR00765
申请日期
2001.05.11
申请人
SAMYANG CORPORATION;SEO, MIN, HYO;YI, YIL, WOONG;YU, JAE, WON