COMPOSITIONS AND METHODS FOR EXTENDING LIFE SPAN

摘要

Specific inhibition of EF-2 kinase results in the significant extension of life span without any adverse effects on behavior, development, and reproduction. Moreover, inhibition of this enzyme decreases the rate of aging and results in a more than two-fold increase in the sexually-active period of the life span. Inhibition of the activity of the enzyme results in increased overall protein turnover, which is positively correlated with the decrease in rate of aging and increase in life span.