发明名称 |
TRANSGENIC ANIMAL |
摘要 |
A transgenic rat containing in its genome a nucleotide sequence encoding a G a subunit protein, which Ga protein subunit is uncoupled from regulation by Regulators of G-Protein Signaling (RGS) proteins, which Gx subunit protein i s eventually the dominant-negative G188S mutant of Gax9, which nucleotide sequence is operatively associated with a neuron-specific expression control sequence, wherein the transgenic rat expresses the GA subunit protein in neural cells resulting in extended D-protein coupled receptor signaling mediated by the Ga subunit protein.
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申请公布号 |
CA2405504(A1) |
申请公布日期 |
2001.11.15 |
申请号 |
CA20012405504 |
申请日期 |
2001.04.24 |
申请人 |
WYETH COMPANY |
发明人 |
HOWLAND, DAVID S.;YOUNG, KATHLEEN;COCKETT, MARK IAN;ROSENZWEIG-LIPSON, SHARON;MARQUIS, KAREN L. |
分类号 |
A01K67/027;C07K14/47;C12N15/09;C12N15/85;(IPC1-7):A01K67/027;A61K49/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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