Stable cell lines which express retinoid receptors and the insulin receptor are prepared and are useful in identifying agonists and antagonists of retinoid receptors. Agonists and antagonists of the RXR receptor can be determined using the cell lines of the invention which are producers of RXR alone; agonists and antagonists of other retinoid receptors can be determined using cell lines transfected with RXR and the desired retinoid receptor.
申请公布号
WO0185787(A2)
申请公布日期
2001.11.15
申请号
WO2001US14554
申请日期
2001.05.07
申请人
ALLERGAN SALES, INC.
发明人
KUSARI, JYOTIRMOY;ZHOU, SHEILA, X.;LIU, HONGZHI;LEWIS, RAMILLA, O.;CHANDRARATNA, ROSHANTHA, A.