MYC TARGETS

摘要

The invention relates to the treatment and diagnosis of cancer and to the development of drugs. The invention provides a catalogue of >350 targets of the myc oncogene family. The invention provides the insight that it is the myc oncogene family itself that provides for the recruitment and adaptation of the in essence normal physiological mechanisms and events to support the essentially neoplastic character of a cancer cell. Herewith the invention provides a method for the treatment of cancer comprising modulating a myc-dependent downstream gene. The invention also provides a method to use one or more gene products of myc-downstream genes as readout in screenings assays to identify drugs. The insight provided by the invention that myc boosts the cellular protein synthesis machinery can be used to optimise cellular production systems for recombinant protein synthesis systems.