发明名称 |
Methods of blocking B-cell activation using anti-CD40 monoclonal antibodies |
摘要 |
Methods for preventing or treating an antibody-mediated diease in a patient are presented, the methods comprising administration of a monoclonal antibody capable of binding to a human CD40 antigen located on the surface of a human B cell, wherein the binding of the antibody to the CD40 antigen prevents the growth or differentiation of the B cell. Monoclonal antibodies useful in these methods, and epitopes immunoreactive with such monoclonal antibodies are also presented.
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申请公布号 |
US6315998(B1) |
申请公布日期 |
2001.11.13 |
申请号 |
US20000504505 |
申请日期 |
2000.02.15 |
申请人 |
CHIRON CORPORATION |
发明人 |
DE BOER MARK;CONROY LEAH B. |
分类号 |
C12N15/02;A61K31/4353;A61K31/436;A61K31/573;A61K38/00;A61K39/395;A61K45/00;A61P1/16;A61P7/06;A61P29/00;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C07K14/705;C07K16/00;C07K16/28;C12N5/10;C12N15/06;C12N15/09;C12P21/02;C12P21/08;G01N33/53;G01N33/531;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/02 |
代理机构 |
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