Novel indole derivatives exhibiting chymase-inhibitory activities and process for preparation thereof

摘要

According to this invention, there is provided an indole derivative having the general formula (I) wherein A is an oxygen atom or a nitrogen atom which nitrogen atom is optionally substituted with an alkyl group, and (i) R<1> and R<2> each stand for a hydrogen atom or an alkyl group, independently, or (ii) R<1> and R<2> as taken together form a cycloalkyl group or an aromatic ring, or (iii) R<1> and R<2> as taken together form a heterocyclic ring, and R<3> is a hydrogen atom, a (C1-C10)alkyl group or others, R<4> is a substituted alkyl group and R<5> is a hydrogen atom, a halogen atom, an alkyl group or an alkoxy group and so on, as novel compounds by a novel chemical synthetic process. The indole derivative of formula (I) exhibits a useful chymase inhibitory activity.