发明名称 |
METHOD FOR PURIFYING AND ISOLATING (2S,3S)- OR (2R,3S)-HALOHYDRIN DERIVATIVES |
摘要 |
<p>The present invention has for its object to provide a practical method for the purification and isolation on a commercial scale of said compound (1) or compound (2) in good yield and with high quality. The present invention provides a purification/isolation method of a (2S,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (1) or a (2R,3S)-1-halo-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane (2) which comprises, for the purpose of removing contaminant impurity from a mixture containing at least one of said compounds(1) and (2), causing the objective compound (1) or compound (2) to be crystallized in the presence of a solvent comprised of a hydrocarbon solvent and then collecting the obtained crystals.</p> |
申请公布号 |
EP1151992(A1) |
申请公布日期 |
2001.11.07 |
申请号 |
EP20000900855 |
申请日期 |
2000.01.21 |
申请人 |
KANEKA CORPORATION |
发明人 |
MAEHARA, KATSUJI;KAWANO, SHIGERU;YAMAGUCHI, MAKOTO;UEDA, YASUYOSHI |
分类号 |
C12P41/00;C07C269/08;C07C271/16;C12P13/02;(IPC1-7):C07C269/08 |
主分类号 |
C12P41/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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