发明名称 |
MODULATOR OF INFLAMMATION |
摘要 |
Two novel DNA binding proteins are provided which bind specifically to DNA target sites within the promoter region of the TNF- alpha gene. Also provided are screening methods based on this DNA-protein interaction which may be used to identify compounds which modulate the expression of TNF- alpha and a genetic screen for susceptibility to inflammatory disease based upon screening for a single nucleotide polymorphism in the TNF- alpha promoter. |
申请公布号 |
EP1151137(A1) |
申请公布日期 |
2001.11.07 |
申请号 |
EP20000902755 |
申请日期 |
2000.02.09 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
KNIGHT, JULIAN CHARLES;KWIATKOWSKI, DOMINIC PETER |
分类号 |
C07K14/525;C12Q1/68;(IPC1-7):C12Q1/68;C12N15/85;C12N5/10;A61K35/00;C07K14/47 |
主分类号 |
C07K14/525 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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