| 摘要 |
This invention provides the complete and correct nucleotide and amino acid sequences of human caspase-14. The invention provides an isolated human caspase-14 nucleic acid, wherein the nucleic acid comprises a coding region encoding human caspase-14 and the coding region comprises a nucleotide sequence ATG AGC AAT CCG COG TCT TTG GAA GAG (SEQ ID NO:3) at its 5' end or the coding region encodes an amino acid sequence Met Ser Asn Pro Arg Ser Leu Glu Glu (SEQ ID NO:4) at its 5' end. The invention also provides an isolated human caspase-14 protein comprising an amino acid sequence Met Ser Asn Pro Arg Ser Leu Glu Glu (SEQ ID NO:4) at its amino terminus. The invention also provides expression vectors, host cells and methods for making human caspase-14 proteins. The invention further provides fusion proteins, antibodies, non-human transgenic animals, and screening assays for identifying compounds which modulate human caspase-14. |
