NEW METHOD FOR PRODUCING D-ASPARTIC ACID

摘要

PROBLEM TO BE SOLVED: To provide a new method for producing D-aspartic acid derivative expressed by formula I (wherein, R1 is a blocking group for amino group; and R2 is an alkyl or the like) by an enzymatic reaction overcoming its deactivation. SOLUTION: This method for producing the D-aspartic acid is provided by reacting a compound of formula II with a protease in an aqueous system at pH 6.0-7.5 combined with an organic co-solvent and then extracting a pure product as a mirror image isomer of formula I.