发明名称 |
INHIBITORS OF DIPEPTIDYL PEPTIDASE IV |
摘要 |
Compounds according to general formula (1), wherein R<1> is H or CN, X<1> is S, O, SO2 or CH2, X<2> is O, S or CH2, X<3> is NR<5> or a carbonyl or thiocarbonyl group and R<4> is R<6>R<7>N, R<8>(CH2)qOC(=O), R<8>(CH2)qOC(=S), R<6>R<7>NC(=O), R<6>R<7>NC(=S); R<8>(CH2)qC(=O), R<8>(CH2)qC(=S) or R<8>(CH2)qSO2, m is 1-3 and n is 0-4 are new. The compounds of the invention are inhibitors of dipeptidyl peptidase IV. Pharmaceutical compositions of the compounds of the invention, or pharmaceutically acceptable salts thereof, are useful in the treatment of, <i>inter alia</i>, type 2 diabetes.
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申请公布号 |
WO0181304(A1) |
申请公布日期 |
2001.11.01 |
申请号 |
WO2001GB01888 |
申请日期 |
2001.04.26 |
申请人 |
FERRING BV;EVANS, DAVID, MICHAEL;PITT, GARY, ROBERT, WILLIAM |
发明人 |
EVANS, DAVID, MICHAEL;PITT, GARY, ROBERT, WILLIAM |
分类号 |
C07D295/18;A61K31/40;A61K31/4025;A61K31/4178;A61K31/422;A61K31/426;A61K31/427;A61K31/437;A61K31/4439;A61K31/454;A61K31/4709;A61K31/4725;A61K31/496;A61K31/497;A61K31/498;A61K31/506;A61K31/5377;A61P3/10;A61P5/06;A61P5/50;A61P15/00;A61P15/08;A61P29/00;A61P37/02;A61P43/00;C07D207/16;C07D213/74;C07D213/82;C07D217/06;C07D217/26;C07D233/84;C07D241/24;C07D277/04;C07D295/185;C07D401/12;C07D403/12;C07D405/12;C07D409/12;C07D413/12;C07D417/08;C07D417/12;C07D417/14;C07D471/04;(IPC1-7):C07D207/16;C07D277/06;C07D417/06;A61K31/425 |
主分类号 |
C07D295/18 |
代理机构 |
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代理人 |
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地址 |
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