发明名称 |
OXAZOLIDINONE DERIVATIVES WITH ANTIBIOTIC ACTIVITY |
摘要 |
Compounds of formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof, wherein HET is an N-linked 5-membered heteroaryl ring, optionally substituted on a C atom by an oxo or thioxo group; and/or by 1 or 2(1-4C) alkyl groups; and/or on an available nitrogen atom by (1-4C)alkyl; or HET is an N-linked 6-membered heteroaryl ring containing up to three nitrogen heteroatoms in total, optionally substituted on a C atom as above; Q is selected from, for example, (Q1), R<2> and R<3> are independently hydrogen or fluoro; T is selected from a range of groups, for example, of formula (TC5), wherein Rc is, for example, R<13>CO-, R<13>SO2- or R<13>CS-; wherein R<13> is, for example, optionally substituted (1-10C)alkyl or R<14>C(O)O(1-6C)alkyl wherein R<14> is optionally substituted (1-10C)alkyl; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.
|
申请公布号 |
WO0181350(A1) |
申请公布日期 |
2001.11.01 |
申请号 |
WO2001GB01815 |
申请日期 |
2001.04.23 |
申请人 |
ASTRAZENECA AB;ASTRAZENECA UK LIMITED;GRAVESTOCK, MICHAEL, BARRY;BETTS, MICHAEL, JOHN;GRIFFIN, DAVID, ALAN;MATTHEWS, IAN, RICHARD |
发明人 |
GRAVESTOCK, MICHAEL, BARRY;BETTS, MICHAEL, JOHN;GRIFFIN, DAVID, ALAN;MATTHEWS, IAN, RICHARD |
分类号 |
C07D491/113;A61K31/42;A61K31/422;A61K31/4245;A61K31/433;A61K31/438;A61K31/454;A61K31/496;A61K31/5377;A61P31/04;C07D413/06;C07D413/14;C07D417/14;C07D491/10;C07D521/00;(IPC1-7):C07D491/10 |
主分类号 |
C07D491/113 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|