CONVERSION OF A WATSON-CRICK DNA TO A HOOGSTEEN-PAIRED DUPLEX
摘要
A method is described for obtaining Hoogsteen-paired pyrimidine*purine duplexes, either by heating a triplex to dissociate a Watson-Crick paired pyrimidine strand or by linking two parallel strands at their 5' ends is disclosed. This duplex can be used as a new type of antisense molecule to pair with an RNA pyrimidine target sequence within an mRNA molecule. This duplex can also be used as a new type of antigene molecule to pair with a single-stranded DNA pyrimidine target sequence within the genome.
申请公布号
WO0105937(A3)
申请公布日期
2001.11.01
申请号
WO2000US19783
申请日期
2000.07.20
申请人
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS;GRAY, DONALD, M.;HASHEM, GIHAN, M.