TWO PORES POTASSIUM CHANNEL MOLECULE AND USES THEREFOR

摘要

The invention provides isolated nucleic acids molecules, designated TWIK-7 nucleic acid molecules, which encode novel TWIK-related potassium channel subunit molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing TWIK-7 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a TWIK-7 gene has been introduced or disrupted. The invention still further provides isolated TWIK-7 proteins, fusion proteins, antigenic peptides and anti-TWIK-7 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.