UTILIZATION OF ADAMTS-1 PROTEIN AND METHOD OF SCREENING AGGRECANASE ACTIVITY REGULATOR

摘要

A novel use of ADAMTS-1 protein or its functionally equivalent modifications; medicinal compositions for treating or preventing diseases caused by abnormal chondral remodeling, medicinal compositions for normalizing abnormal chondral remodeling, and medicinal compositions for decomposing aggrecan, each containing, as the active ingredient, ADAMTS-1 protein or its functionally equivalent modifications; and a method whereby an aggrecanase activity regulator useful in treating or preventing diseases caused by the depression or acceleration of aggrecanase activity can be screened. ADAMTS-1 protein or its functionally equivalent modifications are usable in producing drugs for treating or preventing diseases caused by abnormal chondral remodeling, drugs for normalizing abnormal chondral remodeling or drugs for decomposing aggrecan.