发明名称 |
IMPROVED WATER-INSOLUBLE DRUG PARTICLE PROCESS |
摘要 |
This invention relates to process for the preparation of small particles containing a poorly water soluble drug comprising the steps of (a) mixing at high shear an admixture of a poorly water soluble drug and one or more than one surface active substance in an aqueous carrier in the absence of an organic solvent within a first temperature range at or above the melting poi nt of the poorly water soluble drug to form a heated suspension containing the drug, then (b) homogenizing said heated suspension in a first pressure range and within said first temperature range to form a heated homogenate containi ng the drug, then (c) cooling said heated homogenate to a second temperature range below the melting temperature of the poorly water soluble drug to form a transiently stable cooled homogenate containing the drug, then (d) applying a particle stabilizing energetic process to said cooled homogenate within a second temperature range below the melting point of the drug and in a second pressure range to form a cooled dispersion of stabilized small particles containing the drug, and then (e) optionally drying the cooled dispersion to form dried small particles containing the poorly water soluble drug.
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申请公布号 |
CA2407027(A1) |
申请公布日期 |
2001.11.01 |
申请号 |
CA20012407027 |
申请日期 |
2001.04.20 |
申请人 |
RTP PHARMA INC. |
发明人 |
MISHRA, AWADHESH K.;PACE, GARY |
分类号 |
A61K9/14;A61K9/16;A61K9/19;A61K31/216;A61K31/351;A61K31/4745;A61K47/02;A61K47/10;A61K47/24;A61K47/26;A61K47/36;A61P3/06;B01J13/00;B01J19/00;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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