发明名称 |
ZERO ORDER RELEASE AND TEMPERATURE-CONTROLLED MICROCAPSULES AND PROCESS FOR THE PREPARATION THEREOF |
摘要 |
A microcapsule composition comprising a core material in a matrix of polymorphic shell material, releases said core material in an aqueous environment in accordance with zero order linear release profile. A preferre d composition comprises a core material having a degree of water solubility entrapped in a beta crystalline matrix of water insoluble shell material whi ch matrix may, optionally, be surrounded by a contiguous core material-free lay er of water insoluble shell material. Also disclosed is a process for the preparation of microcapsules comprising subjecting a flowable mixture of cor e material and a first amount of water insoluble shell material to a pressure force to form a pressure-treated mixture, and passing said pressure-treated mixture through a spray nozzle into a chilling zone to form a solidified composition. A special embodiment of the method providing for the long term moisture stability of the resulting microcapsules subjects the microcapsules prepared in the first step to a second coating with a second amount of water insoluble shell material. |
申请公布号 |
CA2407154(A1) |
申请公布日期 |
2001.11.01 |
申请号 |
CA20012407154 |
申请日期 |
2001.04.27 |
申请人 |
VERION, INC |
发明人 |
VAGHEFI, FARID;NALAMOTHU, VIJENDRA;LEE, JEFFRY |
分类号 |
A61K9/52;A61K9/16;A61K9/50;A61K47/02;A61K47/44;B01J2/00;B01J2/02;B01J3/00;B01J13/04;B01J13/22;(IPC1-7):B01J13/04 |
主分类号 |
A61K9/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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