NEW DERIVATIVES OF HYDROSAMIC ACID, PHARMACEUTICAL COMPOSITIONS BASED ON THEM AND METHOD FOR THEIR PREPARATION

摘要

The invention relates to new compounds having the formula where X means halogen, Z is aromatic or pyridinyl group or the like, and R is alkyl or phenylalkyl group, or the group -A-N(R1)R2 where R1 and R2, independent from each other, mean hydrogen or alkyl group or R1 and R2 together with the nitrogen atom to which they are bound form 5- to 7-member saturated heterocylic ring, in a given case additionally containing nitrogen, oxygen or sulphur atom, and this heterocyclic ring in a given case being substituted by at least one alkyl group, and A meaning alkylene group having a straight or branching chain, and to their pharmaceutically acceptable salts, adjunctive to acids. The invention also relates to new intermediate compounds with the formula The compounds with formula I have antiischemic effect and find application for the treatment of, for example, myocardial ischemia, inducted, for example, by coronary artery occlusion. 10 claims