发明名称 |
Sequestrin of Plasmodium falciparum |
摘要 |
In this application is described the expression cloning and functional characterization of the CD36-binding domain of Sequestrin. Sequestrin is a surface protein of 215-250 kD size which does not vary in size between parasite strains. The Sequestrin gene appears to be single-copy-number within the genome; noncytoadherent laboratory parasite strains carry the sequestrin gene but fail to express the protein. Sequestrin binds with high affinity to CD36. Sequestrin protein and sequence can be used as a diagnostic, prognostic, and therapeutic tool.
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申请公布号 |
US6310046(B1) |
申请公布日期 |
2001.10.30 |
申请号 |
US19950559896 |
申请日期 |
1995.11.17 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY |
发明人 |
DUFFY PATRICK E.;OCKENHOUSE CHRISTIAN F. |
分类号 |
A61K38/00;A61K48/00;C07K14/705;C07K16/28;C07K16/42;(IPC1-7):A61K48/00;C12Q1/68;C07H21/00;C12N15/63 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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