| 摘要 |
The present invention relates to a process for the preparation of 3-[(1'-(alkoxycarbonyl)-3'-phenylpropyl)amino]-2-oxo-[1]-benzazepine, whose derivatives are angiotensin-converting enzyme (ACE) inhibitors useful in the treatment of hypertension, chronic heart failure and progressive chronic renal insufficiency. By using a non-natural amino acid ester, L-homophenylalanine alkyl ester, as a key starting material in the condensation with a 3-halo-2,3,4, 5-tetrahydro-1H-1-benzazepine-2-one which can be obtained easily in large quantities, the processes of the present invention can avoid racemization and require fewer steps in the operational procedures and are more practical and economical than conventional processes. |
