| 摘要 |
The present invention relates to compounds of the general formula (I). The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR), wherein R<1>, R<2>, R<3> and R<4> independently of each other are hydrogen, C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, heteroaryl, heteroaralkyl or C1-6-alkoxyC1-6-alkyl, optionally substituted with one or more halogen, hydroxy or amino; and X1, X2, X3 and X4 independently of each other is carbon, oxygen, sulphur or nitrogen; and Y is C1-12-alkyl, C2-12-alkenyl, C2-12-alkynyl, aryl, aralkyl, alkylaralkyl, heteroaryl, heteroaralkyl, or alkylheteroaralkyl, optionally substituted with one or more halogen, hydroxy or amino; and Ar<1> and Ar<2> independently of each other are aryl or heteroaryl optionally substituted with one or more halogen, hydroxy, amino, aminoalkyl, carboxyalkyl, C1-6-alkyl or C1-6-alkoxy; or a salt thereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, including a racemic mixture, or any tautomeric forms. |
