发明名称 |
Haemostatically active preparation containing vwf and method for the production thereof |
摘要 |
Preparation of a composition comprising hemostatically active von Willebrand factor (vWF) comprises (i) chromatographic purification of a vWF-containing plasma fraction; (ii) purifying the collected active fraction by gel permeation to produce a heat-stable fraction and (iii) heating this to inactivate viruses. Preparation of a composition comprising hemostatically active von Willebrand factor (vWF) comprises: (i) chromatographic purification of a vWF-containing plasma fraction on an ion-exchange material (A); (ii) purifying the collected active fraction by gel permeation to produce a heat-stable fraction and (iii) heating this to inactivate viruses. (A) comprises anion-exchange groups on a grafted polymeric structure (a tentacle material). An Independent claim is also included for a hemostatically active vWF-containing composition made this way. |
申请公布号 |
AU6383501(A) |
申请公布日期 |
2001.10.30 |
申请号 |
AU20010063835 |
申请日期 |
2001.04.04 |
申请人 |
OCTAPHARMA AG |
发明人 |
DJURO JOSIC;MONIKA STADLER;GERHARD GRUBER |
分类号 |
A61K35/16;A61P7/02;C07K1/16;C07K14/745;C07K14/755 |
主分类号 |
A61K35/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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