发明名称 |
Treatment of hyperproliferative, inflammatory and related mucocutaneous disorders using inhibitors of mevalonate synthesis and metabolism |
摘要 |
The present invention provides methods for treating a variety of hyperproliferative and inflammatory mucocutaneous disorders, including, basal cell carcinoma, squamous cell carcinoma, psoriasis and atopic dermatitis, as well as skin irritation and disorders associated with skin aging and skin photodamage using inhibitors of cholesterol metabolism. The present invention further relates to the discovery that the combined use of several inhibitors of cholesterol metabolism produces synergistic effects. Furthermore, the present invention is directed to the use of inhibitors of cholesterol metabolism as excipients to enhance the effects of antiinflammatory drugs. |
申请公布号 |
AU5537601(A) |
申请公布日期 |
2001.10.30 |
申请号 |
AU20010055376 |
申请日期 |
2001.04.12 |
申请人 |
CELLEGY PHARMACEUTICALS, INC. |
发明人 |
THOMAS P. PARKS;STEPHEN GRAYSON |
分类号 |
A61K9/00;A61K31/015;A61K31/045;A61K31/047;A61K31/19;A61K31/22;A61K31/235;A61K31/366;A61K31/40;A61K31/4418;A61K31/56;A61K31/575;A61K31/60;A61K38/00;A61K45/06;A61K47/10;A61K47/12;A61K47/14;A61K47/18;A61K47/28;A61K47/32 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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