发明名称 |
Therapeutic treatment and prevention of infections with a bioactive materials encapsulated within a biodegradable-biocompatible polymeric matrix |
摘要 |
Novel burst-free, sustained release biocompatible and biodegrable microcapsules which can be programmed to release their active core for variable durations ranging from 1-100 days in an aqueous physiological environment. The microcapsules are comprised of a core of polypeptide or other biologically active agent encapsulated in a matrix of poly(lactide/glycolide) copolymer, which may contain a pharmaceutically-acceptable adjuvant, as a blend of upcapped free carboxyl end group and end-capped forms ranging in ratios from 100/0 to 1/99.
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申请公布号 |
US6309669(B1) |
申请公布日期 |
2001.10.30 |
申请号 |
US19970789734 |
申请日期 |
1997.01.27 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY |
发明人 |
SETTERSTROM JEAN A.;VAN HAMONT JOHN E.;REID ROBERT H.;JACOB ELLIOT;JEYANTHI RAMASUBBU;BOEDEKER EDGAR C.;MCQUEEN CHARLES E.;JARBOE DANIEL L.;CASSELS FREDERICK;BROWN WILLIAM;THIES CURT;TICE THOMAS R.;ROBERTS F. DONALD;FRIDEN PHIL |
分类号 |
A61K9/16;A61K9/50;A61K9/52;A61K38/17;A61K38/19;A61K39/00;A61K39/02;A61K39/108;A61K39/29;F23G5/50;G05B23/02;(IPC1-7):A61K9/52;A61K47/30 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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地址 |
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