发明名称 |
NANOERYTHROSOME AS BIOACTIVE AGENT CARRIER |
摘要 |
Carriers for pharmacologic agents comprise nanoerythrosomes, which are vesicles prepared by the extrusion of red blood cell ghosts, the average diameter of these vesicles is 0.1 .mu.m; the daunorubicin was covalently linked to nanoerythrosomes and the cytotoxicity of daunorubicin conjugated to nanoerythrosomes was assessed on P388D1 cell line; the results indicated that the cytotoxicity of conjugated daunorubicin was higher than the free daunorubicin, similar results were observed on CDF1 mice bearing grafted P388D1 leukemia tumors; daunorubicin- nanoerythrosome conjugates had a higher antineoplastic activity than the free bioactive agent.
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申请公布号 |
CA2150617(C) |
申请公布日期 |
2001.10.30 |
申请号 |
CA19952150617 |
申请日期 |
1995.05.31 |
申请人 |
GICQUAUD, CLAUDE;POYET, PATRICK;GAUDREAULT, RENE C. |
发明人 |
GICQUAUD, CLAUDE;POYET, PATRICK;GAUDREAULT, RENE C. |
分类号 |
A61K9/50;A61K9/51;A61K47/48;(IPC1-7):C12N5/08;A61K51/04;C12N5/06;A61K51/12;A61K35/18;A61K47/46 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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