| 摘要 |
The present invention provides methods which use 4-amino-azepan-3-one protease inhibitors of cathepsin L in the treatment of diseases in which cathepsin L is implicated, especially treatment or prevention of rheumatoid arthritis; treatment or preventio nof cancer metastasis; treatment or preventio of diseases requiring inhibition of tissue destruction by macrophage, particularly lung macrophage, such as asthma, chronic obstructive pulmonary disease (COPD), and emphysema; treatment or preventoin of diseases requiring, for therapy, inhibition of positive selection of CD4<+>T<-> cells by cortical thymic epithelial cells. |
