GENETIC POLYMORPHISM OF MXA PROTEIN AND APPLICATION THEREOF

摘要

PURPOSE: Provided are genetic polymorphism of MxA proteins and a method for predicting validity of interferon in an individual to be subjected to interferon therapy by using the genetic polymorphism. CONSTITUTION: A polynucleotide for predicting validity of interferon therapy, is characterized by comprising a polynucleotide selected from the group consisting of: (at) the polynucleotide of SEQ ID NO: 1 in the sequence listing; (bt) a modified polynucleotide derived from the polynucleotide (at) by including one or several deletions, substitutions or additions at any positions except for 455th position; (ct) a polynucleotide containing the sequence which spans from 441st to 455th position of SEQ ID NO: 1; (dt) a polynucleotide containing the sequence which spans from 449the to 459th position of SEQ ID NO: 1; and (et) a complementary strand of the polynucleotide selected from the group consisting of (at), (bt), (ct) and (dt) mentioned above.