摘要 |
A phenyl substituted sulphonamide derivative has the formula (I) wherein: P is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; A is a single bond, an alkylene or an alkenylene group; R1 is halogen, alkyl optionally substituted by one or more halogen atoms, cycloalkyl, CO-alkyl, alkoxy, OCF3, hydroxy, hydroxyalkyl, hydroxyalkoxy, alkoxyalkoxy, nitro, amino, alkylamino, dialkylamino, cyano or R1 is phenyl, naphthyl, a bicyclic heterocyclic ring or is a 5 to 7-membered heterocyclic ring each containing 1 to 4 heteroatoms selected from oxygen, nitrogen or sulphur; n is 0, 1, 2, 3, 4, 5 or 6; R2 is hydrogen, alkyl or arylalkyl; R3 is a group R5 or together with R5 forms a group (CH2)2O or (CH2)3O or R3 is linked to R2 to form a group (CH2)2 or (CH2)3; R4 is N-piperazine optionally substituted by alkyl and R5 is hydrogen, halogen, alkyl, cycloalkyl, CO-alkyl, alkoxy, hydroxy, hydroxyalkyl, hydroxyalkoxy, alkoxyalkoxy, nitro, trifluoromethyl, cyano or aryl. A pharmaceutical composition thereof is useful in treating diseases in which the beneficial activity is effected by antagonism of 5-HT6 receptors such as schizophrenia, Alzheimer's disease and depression
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