PEPTIDE NUCLEIC ACID DERIVATIVES WITH A NEGATIVE CHARGE, AGENTS AND METHODS FOR PRODUCING THEM

摘要

The invention relates to PNA derivatives which carry a phosphoryl radical on the N terminus of the PNA backbone, for example a phosphate or a substituted phosphoryl radical, substituted phosphoryl derives optionally carrying one o r more marker groups or groups for cross-linking or groups which favor intracellular take-up or groups which increase the binding affinity of the P NA derivative to nucleic acids. The invention also relates to a method for producing the aforementioned PNA derivatives and to their use as medicaments and diagnostic agents.