METHOD FOR IDENTIFYING REGULATORS OF PROTEIN-ADVANCED GLYCATION END PRODUCT (PROTEIN-AGE) FORMATION
摘要
The invention relates to methods for identifying compounds which affect cellular stress. In particular, the method relates to identifying compounds which inhibit protein advanced glycation end product formation, where the compounds are carbonyl scavengers which inhibit the formation. The assay involves combing the substance of interest with histone H1 and ADP-ribose, and then measuring fluorescence and protein cross linking. Various inhibitors of protein AGE glycation have been identified, using this assay.
申请公布号
WO0179842(A2)
申请公布日期
2001.10.25
申请号
WO2001US12368
申请日期
2001.04.16
申请人
NIADYNE CORPORATION;UNIVERSITY OF KENTUCKY;JACOBSON, ELAINE, L.;JACOBSON, MYRON, K.;WONDRAK, GEORG, THOMAS
发明人
JACOBSON, ELAINE, L.;JACOBSON, MYRON, K.;WONDRAK, GEORG, THOMAS