| 发明名称 |
COMPLEX OF RAS-FARNESYLTRANSFERASE INHIBITOR AND SULFOBUTYLETHER-7-BETA-CYCLODEXTRIN OR 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN AND METHOD |
| 摘要 |
<p>The present invention provides a ras-farnesyltransferase inhibitor complex formed of ras-farnesyltransferase inhibitor or a pharmaceutically acceptable salt thereof and sulfobutylether-7- -cyclodextrin or 2-hydroxypropyl- -cyclodextrin. The complex has unexpectedly high aqueous solubility of the ras-farnesyltransferase inhibitor and is useful for its intravenous delivery to humans with cancer. Also provided is method for forming the complex. The ras-farnesyltransferase inhibitors are useful as anti-tumor agents.</p> |
| 申请公布号 |
LT2001064(A) |
申请公布日期 |
2001.10.25 |
| 申请号 |
LT20010000064 |
申请日期 |
2001.06.21 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
RAGHAVAN,S.KRISHNASWAMY;MALLOY,M.TIMOTHY;VARIA,A.SAILESH </B720 |
| 分类号 |
C07D403/06;A61K9/08;A61K31/55;A61K31/5513;A61K47/12;A61K47/40;A61K47/48;A61P35/00;C07D243/14;C07D409/14;(IPC1-7):A01N43/00 |
主分类号 |
C07D403/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
