发明名称 |
Pharmaceutical compounds |
摘要 |
A compound which is a heteroaromatic[a]phenazine carboxamide derivative of formula (I) wherein X is a five- or six-membered heteroaromatic ring which contains one or two nitrogen atoms and which is unsubstituted or substituted by C1-C6 alkyl, hydroxyl or C1-C6 alkoxy; Q is C1-C6 alkylene which is unsubstituted or substituted by C1-C6 alkyl which is unsubstituted or substituted by a hydroxy group; and R1 and R2 which are the same or different are each C1-C6 alkyl; or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of topoisomerase I and II and can be used to treat tumours, including tumours which express MDR.
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申请公布号 |
US2001034346(A1) |
申请公布日期 |
2001.10.25 |
申请号 |
US20010797902 |
申请日期 |
2001.03.05 |
申请人 |
MILTON JOHN;VICKER NIGEL;DENNY WILLIAM ALEXANDER;GAMAGE SWARNALATHA AKURATIYA;SPICER JULIE ANN |
发明人 |
MILTON JOHN;VICKER NIGEL;DENNY WILLIAM ALEXANDER;GAMAGE SWARNALATHA AKURATIYA;SPICER JULIE ANN |
分类号 |
C07D471/04;C07D487/04;(IPC1-7):A61K31/498;C07D241/46 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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地址 |
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