Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen-binding fragment thereof having binding specificity for alpha 4 beta 7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.
申请公布号
WO0178779(A2)
申请公布日期
2001.10.25
申请号
WO2001US12234
申请日期
2001.04.13
申请人
MILLENNIUM PHARMACEUTICALS, INC.;GENENTECH, INC.;BRETTMAN, LEE, R.;FOX, JUDITH, A.;ALLISON, DAVID, EDWARD
发明人
BRETTMAN, LEE, R.;FOX, JUDITH, A.;ALLISON, DAVID, EDWARD