发明名称 |
MUCOSAL DTPa VACCINES |
摘要 |
<p>Mucosal DTPa vaccines, especially intranasal vaccines, comprising (a) a diphtheria antigen, a tetanus antigen and an acellular pertussis antigen, and (b) a detoxified mutant of cholera toxin (CT) or <i>E.coli</i> heat labile toxin (LT). Component (b) acts as a mucosal adjuvant. The acellular pertussis antigen preferably comprises pertussis holotoxin (PT) and filamentous haemagglutinin (FHA) and, optionally, pertactin. The mucosally-delivered combined DTPa formulation is capable of generating a level of protection against <i>B.pertussis</i> infection equivalent to that observed by alum-adjuvanted parenteral administration.</p> |
申请公布号 |
WO0122993(A3) |
申请公布日期 |
2001.10.25 |
申请号 |
WO2000IB01440 |
申请日期 |
2000.09.28 |
申请人 |
CHIRON S.P.A.;RAPPUOLI, RINO;PIZZA, MARIAGRAZIA |
发明人 |
RAPPUOLI, RINO;PIZZA, MARIAGRAZIA |
分类号 |
A61K9/12;A61K39/05;A61K39/08;A61K39/10;A61K39/116;A61K39/39;A61P31/04;A61P31/10;A61P37/04;(IPC1-7):A61K39/116;A61K39/106;A61K39/108 |
主分类号 |
A61K9/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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