| 摘要 |
<p>The invention relates to a method for obtaining derivatives of [[(pyridil substituted)methyl]thio] benzimidazol (I), wherein R1, R3 and R4 independently represent hydrogen, alkyl, alkoxy or fluorinated alkoxy with 1 to 6 carbon atoms; R2 represents nitro, halogen, alkoxy or halogenated alkoxy with 1 to 6 carbon atoms or a -O-(CH2)n-OR8 group, wherein n is a whole number from 1 to 6 and R8 represents hydrogen or an alkyl group with 1 to 6 carbon atoms. The method involves the following steps: (a) reacting a methylpyridine N-oxide with a carboxylic acid or sulfonic acid anhydride and (b) reacting the intermediate product formed in step (a) with a corresponding mercaptobenzimidazole. The compounds (I) are useful for synthesizing [[(pyridil substituted)methyl]thio] benzimidazol, for instance, omeprazole, lansoprazole, rabeprazole o pantoprazole.</p> |
