发明名称 METHODS FOR PREPARING QUANTITIES OF PRESELECTED POLYNUCLEOTIDE SEQUENCES AND USES THEREOF
摘要 <p>Methods are described for the preparation of quantities of preselected polynucleotide sequences in purified form. The method is independent of length or sequence, and can be used to prepare multi-milligram quantities of, for example, single length, isotope-enriched duplex DNA following a single-step chromatographic purification of the desired product. The method of the present invention allows for preparative scale synthesis of DNA yielding a single product length. The application of the method to NMR spectroscopy of DNA provides the opportunity to identify biologically relevant interactions between polynucleotide sequences and other macromolecules, and assist in the identification and development of agents having therapeutic utility as a consequence of the promotion or antagonism of these interactions.</p>
申请公布号 WO0106017(A3) 申请公布日期 2001.10.25
申请号 WO2000US19969 申请日期 2000.07.20
申请人 THE ROCKEFELLER UNIVERSITY;WERNER, MILTON, H.;GUPTA, VINEET 发明人 WERNER, MILTON, H.;GUPTA, VINEET
分类号 C12N15/10;C12N15/66;C12P19/34;C12Q1/68;(IPC1-7):C12Q1/68 主分类号 C12N15/10
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